https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52595 Wed 13 Mar 2024 14:13:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15270 Wed 11 Apr 2018 16:33:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50026 Tue 27 Jun 2023 16:47:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17935 0.29). Hippocampal surface analysis showed the typical pattern of CA1 and subicular tissue atrophy in both ε4-carriers and non-carriers compared with controls (e4 carriers: p < 0.0002; ε4 non-carriers: p < 0.01, permutation test). The left hippocampal volume was significantly smaller in ε4-carriers than non-carriers (p = 0.044, Mann–Whitney test), the effect of APOE4 mapping to the subicular/CA1 region (p = 0.041, permutation test). Differences were not statistically significant in the right hippocampus (p > 0.20, permutation test). These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by pathology. APOE4 may affect the structural expression of Alzheimer's disease.]]> Sat 24 Mar 2018 07:56:34 AEDT ]]>